| 别名 | NY REN 2, HGRG8, DF2, CLL-associated antigen KW-14, CLL associated antigen KW 14 |
| 产品类型 | Monoclonal |
| 基因名称 | YTH domain family, member 2 |
| 经测试应用 | WB, IF/ICC |
| 宿主 | Rabbit |
| 种属反应性 | Human, Mouse, Rat |
| 免疫原 | A synthesized peptide derived from human YTHDF2 |
| 理论分子量 | 62 kDa |
| 实际分子量 | 65-70 kDa |
| Gene ID(NCBI) | 51441 |
| GeneBank Accession Number | BC002559 |
| UNIPROT | Q9Y5A9 |
| 形式 | Liquid |
| 保存条件 | Store at -20℃. Stable for one year after shipment. Aliquoting is unnecessary for -20℃ storage. |
| 推荐稀释比例 | 1:2500-1:25000 |
| 背景信息 | This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. |