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XBP1S-specific Polyclonal antibody

XBP1S-specific Polyclonal antibody

货号：
AP20164
规格：

20ul

50ul

100ul
价格：
￥0.00

产品说明书前往锐竞购买

产品参数

别名	XBP1, Tax-responsive element-binding protein 5, TREB-5, X box binding protein 1,X-box-binding protein 1
产品类型	Polyclonal
基因名称	X-box binding protein 1
经测试应用	WB, IHC
宿主	Rabbit
种属反应性	Human, Mouse, Rat
免疫原	A synthesized peptide derived from human XBP1
理论分子量	29 kDa
实际分子量	55 kDa
Gene ID(NCBI)	7494
GeneBank Accession Number	‍‍BC000938‍
UNIPROT	P17861
形式	Liquid
保存条件	Store at -20℃. Stable for one year after shipment. Aliquoting is unnecessary for -20℃ storage.
推荐稀释比例	1:500-1:3000
背景信息	This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.

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