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NLRP3 Mouse Monoclonal antibody

NLRP3 Mouse Monoclonal antibody

3H1A7, Angiotensin/vasopressin receptor AII/AVP-like, C1orf7, CIAS1, Cold-induced autoinflammatory syndrome 1 protein

货号：
AM20203
规格：

20ul

50ul

100ul
价格：
￥0.00

产品说明书

产品参数

产品类型	Monoclonal
基因名称	NLR family, pyrin domain containing 3
经测试应用	WB, IHC, IF/ICC
宿主	Mouse
种属反应性	Human
免疫原	A synthesized peptide derived from human NLRP3
理论分子量	118 kDa
实际分子量	110 kDa
Gene ID(NCBI)	114548
GeneBank Accession Number	‍‍‍NM_001079821‍
UNIPROT	Q96P20
形式	Liquid
保存条件	Store at -20℃. Stable for one year after shipment. Aliquoting is unnecessary for -20℃ storage.
推荐稀释比例	1:1000-1:5000
背景信息	This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NLRP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. The SARS-CoV 3a protein, a transmembrane pore-forming viroporin, has been shown to activate the NLRP3 inflammasome via the formation of ion channels in macrophages. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, neonatal-onset multisystem inflammatory disease (NOMID), keratoendotheliitis fugax hereditarian, and deafness, autosomal dominant 34, with or without inflammation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

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