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MLKL Monoclonal antibody

MLKL Monoclonal antibody

货号：
AM20179
规格：

20ul

50ul

100ul
价格：
￥0.00

产品说明书前往锐竞购买

产品参数

别名	3D4C6, hMLKL, Mixed lineage kinase domain-like protein
产品类型	Monoclonal
基因名称	mixed lineage kinase domain-like
经测试应用	WB, IHC, IF/ICC, IF-P
宿主	Mouse
种属反应性	Human, Mouse
免疫原	A synthesized peptide derived from human MLKL
理论分子量	54 kDa
实际分子量	45-55 kDa
Gene ID(NCBI)	197259
GeneBank Accession Number	‍‍‍‍‍‍‍‍BC028141‍
UNIPROT	‍‍‍‍‍Q8NB16‍
形式	Liquid
保存条件	Store at -20℃. Stable for one year after shipment. Aliquoting is unnecessary for -20℃ storage.
推荐稀释比例	1:2000-1:20000
背景信息	This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

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