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GRP78/BIP Monoclonal antibody

GRP78/BIP Monoclonal antibody

货号：
AM20166
规格：

20ul

50ul

100ul
价格：
￥0.00

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产品参数

别名	BIP, GRP78, HSPA5, 1D6F7, 78 kDa glucose-regulated protein
产品类型	Monoclonal
基因名称	heat shock 70kDa protein 5
经测试应用	WB, IHC, IF/ICC
宿主	Mouse
种属反应性	Human, Mouse, Rat
免疫原	A synthesized peptide derived from human GRP78/BIP
理论分子量	78 kDa
实际分子量	70-78 kDa
Gene ID(NCBI)	3309
GeneBank Accession Number	‍‍‍BC020235‍
UNIPROT	‍P11021‍
形式	Liquid
保存条件	Store at -20℃. Stable for one year after shipment. Aliquoting is unnecessary for -20℃ storage.
推荐稀释比例	1:2500-1:25000
背景信息	The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers.

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