| 别名 | IL18, Pre-IL18, 5C6F8, Iboctadekin, IFN-gamma-inducing factor |
| 产品类型 | Monoclonal |
| 基因名称 | IL-18 |
| 经测试应用 | WB, IHC, IF/ICC, IF-P |
| 宿主 | Mouse |
| 种属反应性 | Human |
| 免疫原 | A synthesized peptide derived from human IL-18 |
| 理论分子量 | 22 kDa |
| 实际分子量 | 10-15 kDa |
| Gene ID(NCBI) | 3606 |
| GeneBank Accession Number | BC007461 |
| UNIPROT | Q14116 |
| 形式 | Liquid |
| 保存条件 | Store at -20℃. Stable for one year after shipment. Aliquoting is unnecessary for -20℃ storage. |
| 推荐稀释比例 | 1:500-1:5000 |
| 背景信息 | The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |