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抑制剂/激活剂

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凋亡与自噬

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LY 345899

LY 345899 是一种叶酸的类似物，也是一种亚甲基四氢叶酸脱氢酶 (MTHFD1; DC301) 和 MTHFD2 抑制剂，其 IC50 值分别为 96 nM 和 663 nM，对 MTHFD1 的 Ki 值为 18 nM。

货号：
TK0637
规格：

1mg

5mg
价格：
￥0.00

产品参数

CAS No.	10538-99-5
生物活性	LY 345899 is a Folate analog and is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inbhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 18 nM for MTHFD1.
分子量	471.42
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 125 mg/mL (265.16 mM; Need ultrasonic)
体内研究	LY345899 (Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks) shows potent antitumor activity and displays therapeutic activity against CRC in vivo.
体外研究	LY 345899 could suppress the MTHFD enzyme in the cytoplasm and mitochondria. LY 345899 could disturb the NADPH and redox homeostases and accelerate cell death under oxidative stress, such as hypoxia, or causing in vitro anchorage independence and in vivo impaired tumor growth and metastasis.
文献	•Cancers (Basel). 2021 Jan 23;13(3):425. •bioRxiv. 2021 Feb 3.
纯度及产品资料	98%

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