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抑制剂/激活剂

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凋亡与自噬

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Estradiol 雌二醇; β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol

Estradiol 是一种类固醇性激素，对维持女性的生育能力和第二性征至关重要。Estradiol 通过雌激素受体 β (ERβ) 途径上调 IL-6 表达。

货号：
TK0623
规格：

100mg

500mg

1g
价格：
￥0.00

产品参数

CAS No.	50-28-2
生物活性	Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
分子式	C18H24O2
分子量	272.38
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : ≥ 50 mg/mL (183.57 mM) Ethanol : 20 mg/mL (73.43 mM; Need ultrasonic)
体内研究	Estradiol functions in hippocampal synapse density during the estrous cycle in the adult rat. Estradiol reverses the ovariectomy-induced decrease in spine density. Estradiol in combination with progesterone enhances spine density for 2 to 6 h but decreases following estradiol alone. Estradiol (0.2 mg/kg; i.p.; C57BL/6 female mice) plus 10 or 20 mg/kg progesterone, enhances memory consolidation in young ovariectomized mice.
体外研究	Estradiol causes new dendritic spines and synapses in hippocampal CA1 pyramidal cells. Estradiol increases NMDA receptor binding by 46% in parallel with dendritic spine and synapse density. Estradiol also elevates sensitivity of CA1 pyramidal cells to NMDA receptor-mediated synaptic input and such an effect is correlated with the estradiol-induced increase in dendritic spine density in the apical dendritic tree of these cells. Estradiol reduces Ba entry reversibly via Ca channels in acutely dissociated and cultured neostriatal neurons. Estradiol also reduces Ba currents but is significantly less effective than Estradiol in rat neostriatal neurons.
文献	•Theranostics. 2020 Aug 29;10(24):10874-10891. •Cell Death Dis. 2020 Oct 6;11(10):831. •Environ Pollut. 2021 Oct 14;118370. •Environ Pollut. 2021 Feb 1;270:116015. •Pharmacol Res. 2021 Dec 29;106050. •Hum Reprod. 2019 May 1;34(5):804-812. •Biomed Pharmacother. 2019 May 25;116:109001. •Cell Commun Signal. 2019 Aug 14;17(1):94. •Pain. 2021 Jun 1;162(6):1882-1896. •Neurobiol Stress. 2020 Oct 14;13:100256. •J Clin Endocrinol Metab. 2021 Feb 1;dgab020. •J Cell Mol Med. 2020 Jan;24(2):1599-1613. •J Ethnopharmacol. 2021 Mar 23;114064. •PLoS One. 2020 Oct 1;15(10):e0239659. •Aquacult Rep. February 2022, 100930. •Zygote. 2021 Oct 27;1-8. •Research Square Preprint. 2020 Nov 4;rs.3.rs-100914.
纯度及产品资料	98%

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