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抑制剂/激活剂

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凋亡与自噬

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Erteberel LY500307

Erteberel (LY500307) 是有效，选择性的雌激素受体 β (ERβ) 激动剂，Ki 和 EC50 分别为1.54 nM，3.61 nM。抗肿瘤活性。

货号：
TK0622
规格：

1mg

5mg
价格：
￥0.00

产品参数

CAS No.	533884-09-2
生物活性	Erteberel (LY500307) is a potent and selective estrogen receptor beta (ERβ) agonist with Ki and EC50 of 1.54 nM and 3.61 nM, respectively. Anti-tumor activities.
分子式	C18H18O3
分子量	282.33
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : ≥ 30 mg/mL (106.26 mM)
体内研究	Erteberel (5 mg/Kg body weight/day, oral, 28 days) treatment significantly reduces tumor growth and promotes apoptosis of GBM tumors in an orthotopic model. Erteberel (5 mg/Kg body weight/day, oral, 40-50 days) treatment improves the overall survival of tumor-bearing mice in the GL26 syngeneic glioma model.
体外研究	Treatment with Erteberel (0.25-10 μM, 72 hours) significantly reduces the proliferation of GBM cells with no activity on normal astrocytes in vitro. Erteberel promotes apoptosis of GBM cells. Erteberel modulated several pathways related to apoptosis, cell cycle, and DNA damage response. Erteberel (0-1000 μM) sensitizes GBM cells to several FDA-approved chemotherapeutic drugs including cisplatin, lomustine and temozolomide.
文献	•Cell Death Discov. 2021 Jul 22;7(1):189. •Research Square Preprint. 2021 Feb.
纯度及产品资料	98%

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