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抑制剂/激活剂

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凋亡与自噬

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Bicalutamide 比卡鲁胺

Bicalutamide 是一种具有口服活性的非甾体雄激素受体 (AR) 拮抗剂。Bicalutamide 可用于前列腺癌的研究。

货号：
TK0620
规格：

10mg

25mg

50mg

100mg

200mg
价格：
￥0.00

产品参数

CAS No.	90357-06-5
生物活性	Bicalutamide is an orally active non-steroidal androgen receptor (AR) antagonist. Bicalutamide can be used for the research of prostate cancer.
分子式	C18H14F4N2O4S
分子量	430.37
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : ≥ 50 mg/mL (116.18 mM)
体内研究	Bicalutamide (10 mg/kg; i.g.; daily; for 28 days) exhibits anti-tumor activity in prostate cancer mice model.
体外研究	Bicalutamide competes with androgens for binding AR in in a whole-cell binding-assay (LNCaP/AR(cs) cells), with an IC50 of 160 nM. Bicalutamide induces proliferation of VCaP cells in a dose-dependent manner, whereas partially antagonizes the effects of R1881 (synthetic androgen).
文献	•Cell Death Dis. 2021 Jul 27;12(8):740. •Sci Rep. 2017 Jun 8;7(1):3058. •J Drug Deliv Sci Technol. 2021, 102340. •EJNMMI Res. 2018 Oct 29;8(1):96. •Research Square Preprint. 2020 Nov 4;rs.3.rs-100914. •RNA & Disease. 2020 Apr. •Royal Society of Chemistry. 2020,10, 10254-10262.
纯度及产品资料	98%

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