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凋亡与自噬

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Cytarabine 阿糖胞苷; Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C

Cytarabine 是一种核苷类似物，可引起 S 期细胞周期停滞并抑制 DNA聚合酶。Cytarabine 抑制DNA 合成的IC50为16 nM。Cytarabine 对 HSV 具有抗病毒作用。

货号：
TK0616
规格：

100mg

500mg

1g
价格：
￥0.00

产品参数

CAS No.	147-94-4
生物活性	Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV.
分子式	C9H13N3O5
分子量	243.22
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	H2O : 48 mg/mL (197.35 mM; Need ultrasonic) DMSO : 17.3 mg/mL (71.13 mM; Need ultrasonic and warming)
体内研究	Cytarabine (250 mg/kg) also causes placental growth retardation and increases placental trophoblastic cells apoptosis in the placental labyrinth zone of the pregnant Slc:Wistar rats, which increases from 3 hour after the treatment and peaks at 6 hour before returning to control levels at 48 hour, with remarkably enhanced p53 protein, p53 trancriptional target genes such as p21, cyclinG1 and fas and caspase-3 activity. Cytarabine is highly effective against acute leukaemias, which causes the Cytarabine teristic G1/S blockage and synchronization, and increases the survival time for leukaemic Brown Norway rats in a weak dose-related fashion indicating that the use of higher dosages of Cytarabine does not contribute to its antileukaemic effectiveness in man.
体外研究	Cytarabine is phosphorylated into a triphosphate form (Ara-CTP) involving deoxycytidine kinase (dCK), which competes with dCTP for incorporation into DNA, and then blocks DNA synthesis by inhibiting the function of DNA and RNA polymerases. Cytarabine displays a higher growth inhibitory activity towards wild-type CCRF-CEM cells compared to other acute myelogenous leukemia (AML) cells with IC50 of 16 nM. Cytarabine apparently induces apoptosis of rat sympathetic neurons at 10 μM, of which 100 μM shows the highest toxicity and kills over 80% of the neurons by 84 hours, involving the release of mitochondrial cytochrome-c and the activation of caspase-3, and the toxicity can be attenuated by p53 knockdown and delayed by bax deletion.
文献	•Cell. 2018 Sep 20;175(1):171-185.e25. •Leukemia. 2021 Mar 29. •Cell Death Dis. 2021 Jan 5;12(1):20. •Stem Cell Reports. 2021 Nov 9;16(11):2659-2673. •Clin Chem. 2019 Dec;65(12):1522-1531. •Acta Pharmacol Sin. 2021 Jan;42(1):108-114. •J Virol. 2021 Jan 6;JVI.01272-20. •Mol Pharm. 2021 Mar 29. •Front Genet. 05 August 2021. •Eur J Pharmacol. 2021 Dec 22;174722. •J Mol Med (Berl). 2019 Aug;97(8):1183-1193. •Mol Brain. 2020 Dec 10;13(1):166. •Neurotox Res. 2021 Oct 15. •Biomed Mater. 2020 Apr 28;15(3):035016. •SLAS Discov. 2018 Aug;23(7):687-696. •Biol Pharm Bull. 2021 Oct 1. •Fish Shellfish Immunol. 2019 Sep;92:889-896.
纯度及产品资料	98%

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