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抑制剂/激活剂

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凋亡与自噬

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Amphotericin B 两性霉素B

Amphotericin B是针对多种真菌病原体的多烯抗真菌 (fungal) 剂。它与麦角甾醇不可逆地结合，导致膜完整性破坏并最终导致细胞死亡。

货号：
TK0612
规格：

25mg

50mg

100mg
价格：
￥0.00

产品参数

CAS No.	1397-89-3
生物活性	Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
分子式	C47H73NO17
分子量	924.08
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	4°C, protect from light
溶解性数据	DMSO : 83.33 mg/mL (90.18 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)
体内研究	Amphotericin B results in prolonging the incubation time and decreasing PrPSc accumulation in the hamster scrapie model. Amphotericin B markedly reduces PrPSc levels in mice with transmissible subacute spongiform encephalopathies (TSSE). Amphotericin B exerts a direct effect on Plasmodium falciparum and influences eryptosis of infected erythrocytes, parasitemia and hostsurvival in murine malaria. Amphotericin B tends to delay the increase of parasitemia and significantly delays host death plasmodium berghei-infected mice.
体外研究	Amphotericin B administration is limited by infusion-related toxicity, including fever and chills, an effect postulated to result from proinflammatory cytokine production by innate immune cells. Amphotericin B induces signal transduction and inflammatory cytokine release from cells expressing TLR2 and CD14. Amphotericin B interacts with cholesterol, the major sterol of mammal membranes, thus limiting the usefulness of Amphotericin B due to its relatively high toxicity. Amphotericin B is dispersed as a pre-micellar or as a highly aggregated state in the subphase. Amphotericin B only kills unicellular Leishmania promastigotes (LPs) when aqueous pores permeable to small cations and anions are formed. Amphotericin B (0.1 mM) induces a polarization potential, indicating K leakage in KCl-loaded liposomes suspended in an iso-osmotic sucrose solution. Amphotericin B (0.05 mM) exhibits a nearly total collapse of the negative membrane potential, indicating Na entry into the cells.
文献	•Front Cell Infect Microbiol. 2020 Jun 26;10:320. •Neuropharmacology. 2019 Apr 4;151:33-44. •J Virol. 2020 Nov 23;94(24):e01350-20. •Molecules. 2020 Apr 23;25(8):1980. •Am J Physiol Cell Physiol. 2019 Aug 1;317(2):C277-C286. •J Appl Microbiol. 2021 Apr;130(4):1154-1172. •Evid Based Complement Alternat Med. 2015;2015:639412. •J Mycol Med. 9 November 2021, 101227.
纯度及产品资料	750ug/mg

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