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抑制剂/激活剂

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凋亡与自噬

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Dynasore

Dynasore是可渗透细胞的发动蛋白抑制剂，IC50为15 μM。

货号：
TK0609
规格：

1mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	304448-55-3
生物活性	Dynasore is a cell-permeable dynamin inhibitor with an IC50 of 15 μM.
分子式	C18H14N2O4
分子量	322.31
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : ≥ 50 mg/mL (155.13 mM)
体内研究	Dynasore ameliorates the motor dysfunction greatly at 3, 7, and 10 days after SCI in rats. Dynasore significantly enhances motor function which may be by inhibiting the activation of neuronal mitochondrial apoptotic pathway and astrocytic proliferation in rats after SCI.
体外研究	Dynasore interferes with the GTPase activity of dynamin1, dynamin2, and Drp1, the mitochondrial dynamin, but not of other small GTPases. Dynasore acts as a potent inhibitor of endocytic pathways known to depend on dynamin by rapidly blocking coated vesicle formation within seconds of dynasore addition. Two types of coated pit intermediates accumulate during dynasore treatment, g-shaped, half formed pits and O-shaped, fully formed pits, captured while pinching off. Dynasore inhibits HSV-1 and HSV-2 infection of human epithelial and neuronal cells, including primary genital tract cells and human fetal neurons and astrocytes. Dynasore reduces the number of viral capsids reaching the nuclear pore if added at the time of viral entry and that, when added as late as 8 h postentry, dynasore blocks the transport of newly synthesized viral proteins from the nucleus to the cytosol. Dynasore prevents ischemia/reperfusion induced elevation of left ventricular end diastolic pressure. Dynasore also decreases cardiac troponin I efflux during reperfusion and reduces infarct size. In cultured adult mouse cardiomyocytes subjected to oxidative stress, dynasore increases cardiomyocyte survival and viability.
文献	•Nat Nanotechnol. 2020 Dec;15(12):1043-1052. •J Extracell Vesicles. 2021 Jul;10(9):e12117. •J Am Chem Soc. 2018 Dec 12;140(49):17234-17240. •Nat Commun. 2021 Jun 9;12(1):3481. •Small Methods. 2020 Dec 18. •Nano Lett. 2019 Nov 13;19(11):8010-8020. •J Hazard Mater. 2021 Sep 5;417:126092. •Oncogene. 2018 Jan 4;37(1):116-127. •Sci Bull. 2020 Jul. •Comput Struct Biotec. 2021;19:1933-1943. •Anal Chem. 2020 Jan 21;92(2):2103-2111. •PLoS Pathog. 2021 Jul 21;17(7):e1009752. •Front Cell Dev Biol. 2021 Jul 7;9:687322. •Drug Deliv. 2018 Nov;25(1):1066-1079. •Cell Commun Signal. 2020 Nov 4;18(1):176. •J Virol. 2021 Sep 29;JVI0134521. •Arab J Chem. 2020, 13 (1): 2558-2567. •Sci China Life Sci. 2021 May 27;1-21. •Eur J Pharmacol. 2021 May 25;174203. •Neurotox Res. 2019 Jul;36(1):108-116. •Virus Res. 2020 Jan 15;276:197806. •Eur J Cell Biol. 2019 Jan;98(1):36-50. •Research Square Preprint. 2021 Aug.
纯度及产品资料	98%

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