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抑制剂/激活剂

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凋亡与自噬

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NSC 23766 trihydrochloride

NSC 23766 trihydrochloride

NSC 23766 trihydrochloride 是 Rac1 激活的抑制剂。

货号：
TK0583
规格：

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	1177865-17-6
生物活性	NSC 23766 trihydrochloride is an inhibitor of Rac1 activation.
分子式	C24H35N7.3[HCl]
分子量	530.96
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 33.33 mg/mL (62.77 mM; Need ultrasonic) H2O : ≥ 32 mg/mL (60.27 mM)
体内研究	NSC23766 (2.5 mg/kg/day, i.p.) significantly attenuates the onset of spontaneous diabetes in NOD mice, without significant effects on the growth (body weights) of the mice. NSC23766 significantly increases the expression of Rac1 and CHOP, a marker for ER-stress, in islets from NOD mice.
体外研究	NSC 23766 (100 μM) treatment effectively inhibits polar body emission in a dose-dependent manner. NSC 23766 (200 μM) increases the percentage of morphologically abnormal spindles of oocytes. In NSC 23766-treated oocytes, the p-MAPK protein expression is significantly decreased. NSC23766 (50 μM) plus 100 ng/mL Jagged1, GDF9 and BMP15, reduces the number of germLine cell cysts and increases the number of primordial follicles. NSC23766 significantly inhibits GTP-Rac1 activity and phosphorylation of Rac1-PAK, ERKs and p38 MAPK in the spinal dorsal horn neurons.
文献	•Adv Sci (Weinh). 2021 Mar 8;8(10):2004000. •Bioact Mater. 2021 Jun 1. •Front Immunol. 2021 Aug 2;12:686846. •Front Immunol. 02 August 2021. •Comput Struct Biotec. 2021;19:1933-1943. •Food Chem Toxicol. 2020 Dec 24;148:111926. •Food Funct. 2021 Jan 7;12(1):154-161. •J Cell Mol Med. 2020 Mar;24(6):3582-3592. •J Agric Food Chem. 2021 Oct 25. •CNS Neurosci Ther. 2021 Feb 3. •J Inorg Biochem. 13 January 2022, 111725. •Biol Pharm Bull. 2021 Sep 1;44(9):1263-1271. •Research Square Preprint. 2020 Jul.
纯度及产品资料	98%

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