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抑制剂/激活剂

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凋亡与自噬

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U-46619 9,11-Methanoepoxy PGH2

U-46619 (9,11-Methanoepoxy PGH2) 是一种稳定的血栓素 A2 (TXA2) 的类似物，也是一种有效的 TXA2 激动剂。

货号：
TK0582
规格：

1mg

5mg
价格：
￥0.00

产品参数

CAS No.	56985-40-1
生物活性	U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of thromboxane A2 (TXA2) and acts as a potent TXA2 agonist.
分子式	C21H34O4
分子量	350.49
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Solution, -20°C, 2 years
体内研究	U-46619 (5 μg/kg; i.v.) increases blood pressure in male spontaneously hypertensive rats (SHR).
体外研究	U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC50s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively. U-46619 (10 nM-10 μM) increases internal Ca concentration ([Ca]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency. U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets. U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways.
文献	•J Agric Food Chem. 2022 Jan 12.
纯度及产品资料	≥98%

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