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抑制剂/激活剂

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凋亡与自噬

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Dabigatran 达比加群

Dabigatran是一种有效的非肽类凝血酶抑制剂，无细胞试验中IC50为9.3 nM。

货号：
TK0566
规格：

2mg

5mg

10mg
价格：
￥0.00

产品参数

CAS No.	211914-51-1
生物活性	Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM).
分子式	C25H25N7O3
分子量	471.51
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder, -20°C ,3 years
溶解性数据	0.1 M HCL : 12.5 mg/mL (26.51 mM; Need ultrasonic)，H2O : < 0.1 mg/mL (insoluble)，DMSO : < 1 mg/mL (insoluble or slightly soluble)
体内研究	Dabigatran (0.01-0.1 mg/kg; i.v.) inhibits clot formation with an ED50 of 0.033 mg/kg in Wessler model.
体外研究	Dabigatran (BIBR 953) shows concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human platelet-poor plasma at concentrations of 0.23, 0.83 and 0.18 μM, respectively.
纯度及产品资料	98%

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