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抑制剂/激活剂

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凋亡与自噬

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Pemigatinib INCB054828

Pemigatinib (INCB054828) 是一种具有口服活性的，选择性 FGFR 抑制剂，对于 FGFR1，FGFR2，FGFR3，FGFR4 的 IC50 分别为 0.4 nM，0.5 nM，1.2 nM，30 nM。Pemigatinib 有用于胆管癌的潜力。

货号：
TK0555
规格：

1mg

5mg

10mg

25mg
价格：
￥0.00

产品参数

CAS No.	1513857-77-6
生物活性	Pemigatinib (INCB054828) is an orally active, selective FGFR inhibitor with IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively. Pemigatinib has the potential for cholangiocarcinoma.
分子式	C24H27F2N5O4
分子量	487.50
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 25 mg/mL (51.28 mM; ultrasonic and warming and heat to 60°C)
体外研究	This hypothesis is corroborated with in vitro cell-based studies in which cells expressing FGFR2-CLIP1 fusion are sensitive to Pemigatinib (INCB054828; IC50 value of 10.16 nM), whereas cells with the addition of the N549H mutation are resistant to Pemigatinib (IC50 value of 1527.57 nM).
文献	•NPJ Precis Oncol. 2021 Jul 16;5(1):66.
纯度及产品资料	98%

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