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抑制剂/激活剂

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凋亡与自噬

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HA130

HA130 是一种选择性自分泌运动因子 (autotaxin, ATX) 抑制剂，IC50 为 28 nM。

货号：
TK0541
规格：

2mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	1229652-21-4
生物活性	HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM.
分子式	C24H19BFNO5S
分子量	463.29
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder, -20°C ,3 years
溶解性数据	DMSO : ≥ 39 mg/mL (84.18 mM)
体内研究	HA130 slows T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle.The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs).
体外研究	HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation.
纯度及产品资料	98%

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