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抑制剂/激活剂

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凋亡与自噬

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MS436

MS436是一种有效的BET bromodomain抑制剂，对BRD4 (1) 和 BRD4 (2)的Ki分别为<0.085 μM 和 0.34 μM。

货号：
TK0540
规格：

1mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	1395084-25-9
生物活性	MS436 is a new class of bromodomain inhibitor, exhibits potent affinity of an estimated Ki=30-50 nM for the BRD4 BrD1 and a 10-fold selectivity over the BrD2.
分子式	C18H17N5O3S
分子量	383.42
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20℃ 3 years
溶解性数据	DMSO : 25.5 mg/mL (66.51 mM; Need ultrasonic and warming)
体外研究	MS436, through a set of water-mediated interactions, exhibits low nanomolar affinity (estimated Ki of 30-50 nM) with preference for the first bromodomain over the second. MS436 effectively inhibits BRD4 activity in NF-κB-directed production of NO and pro-inflammatory cytokine interleukin-6 in murine macrophages. MS436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression. MS436 exhibits potent affinity of an estimated Ki=30-50 nM for the BRD4 BrD1 and a 10-fold selectivity over the BrD2, which is achieved through a unique set of water-mediated intermolecular interactions.
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纯度及产品资料	98%

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