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抑制剂/激活剂

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凋亡与自噬

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Lovastatin 洛伐他汀

Lovastatin是一种HMG-CoA还原酶抑制剂，无细胞试验中IC50为3.4 nM，用于降胆固醇（降脂药）。Lovastatin 可触发自噬。

货号：
TK0538
规格：

10mg

50mg

100mg
价格：
￥0.00

产品参数

CAS No.	75330-75-5
生物活性	Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.
分子式	C24H36O5
分子量	404.54
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder, -20°C ,3 years
溶解性数据	DMSO : ≥ 100 mg/mL (247.19 mM)
体内研究	Lovastatin is an inactive lactone that is hydrolyzed in the liver to an active f3-hydroxyacid form. This principal metabolite is the inhibitor of the enzyme HMG-CoA reductase. The Ki is 1 nM. Lovastatin and its β-hydroxyacid metabolite are highly bound to human plasma proteins. Lovastatin crosses the blood-brain and placental barriers. Lovastatin produces a profound reduction of apolipoprotein-B-containing lipoproteins, especially LDL cholesterol and, to a lesser extent, plasma triglycerides, and a small increase in HDL cholesterol.
体外研究	Lovastatin (10 μM; 72 hours) efficiently reduces viability of HepG2 cells.Lovastatin (10 μM; 48 hours) induces apoptosis in HepG2 cells.
纯度及产品资料	98%

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