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抑制剂/激活剂

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凋亡与自噬

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ONX-0914 (PR-957)

ONX-0914 (PR-957) PR-957

ONX-0914 (PR-957)是一种有效的，选择性immunoproteasome抑制剂，无细胞试验中对组成型蛋白酶体具有最低的交叉反应性。

货号：
TK0522
规格：

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	960374-59-8
生物活性	ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 μM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1.
分子式	C31H40N4O7
分子量	580.67
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder, -20°C ,3 years
溶解性数据	DMSO : ≥ 35 mg/mL (60.28 mM)
体内研究	ONX-0914 (2-10 mg/kg; i.v,; on days 4, 6 and 8) meliorates disease in mouse arthritis.ONX-0914 (2, 6 and 10 mg per kg body weight on days 25, 27, 29, 31 and 33; i.v.) treatment also induced a rapid therapeutic response in the T and B cell–dependent CIA (collagen-induced arthritis) model.
体外研究	ONX-0914 inhibits LMP7-specific antigen presentation. ONX-0914 blocks cytokine productionby mouse splenocytes and blocks T celldifferentiation.
纯度及产品资料	98%

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