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抑制剂/激活剂

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凋亡与自噬

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IWR-1 endo-IWR 1; IWR-1-endo

IWR-1是端锚聚合酶抑制剂，抑制Wnt/β-catenin信号传导途径。

货号：
TK0501
规格：

1mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	1127442-82-3
生物活性	IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
分子式	C25H19N3O3
分子量	409.44
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : ≥ 46 mg/mL (112.35 mM)
体外研究	Both IWR-1 and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects in vitro. IWR-1 exerts its effect via interaction with Axin, while XAV939 binds TNKS directly. IWR-1 (10 μM) induces stabilization of β-catenin disruption complex. IWR-1 (10 μM) is added to the medium together with MIF, the size of cell colonies is extremely decreased, and that indicates the promoting effect of MIF on NSPC proliferation is inhibited by IWR-1 in any MIF concentration group. 2, 5 and 10 μM of IWR-1 significantly inhibits the proliferation of NSPC dose-dependently. IWR-1 inhibites the promoting effect of MIF on NSPC differentiation to neuron lineage. IWR-1 treatment in the presence of maximal stimulatory dose of FSH (0.5 ng/mL) results in a dose dependent inhibition of the stimulatory effect of FSH with > 75% inhibition observed at the maximal inhibitory dose of IWR-1 (1 µM). IWR-1 treatment partially reverses the FSH-induced inhibition of granulosa cell CARTPT mRNA expression.
文献	•Cell Biosci. 2019 Jun 14;9:48. •Oxid Med Cell Longev. 16 Aug 2021. •Cancer Cell Int. 2019 Nov 27;19:314. •iScience. 2019 Sep 27;19:1248-1259. •J Orthop Transl. 2020 Mar 28;23:29-37. •Oncol Rep. 2018 Aug;40(2):877-886. •Cell Biol Int. 2017 May;41(5):534-543. •Aquacul Rep. 2021, 100774. •Cytotechnology. 2021 Feb 26. •Ren Fail. 2019 Nov;41(1):159-166. •Research Square Preprint. 2021 Jun. •Curr Protoc Cell Biol. 2018 Dec;81(1):e62.
纯度及产品资料	98%

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