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抑制剂/激活剂

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凋亡与自噬

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Cyclopamine 环巴胺; 11-Deoxojervine

Cyclopamine 是 Hedgehog 通路的拮抗剂，在细胞实验中的 IC50 为 46 nM。Cyclopamine 还是一种选择性的 Smo 抑制剂。

货号：
TK0500
规格：

5mg

10mg
价格：
￥0.00

产品参数

CAS No.	4449-51-8
生物活性	Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.
分子式	C27H41NO2
分子量	411.62
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	Ethanol : 33.33 mg/mL (80.97 mM; Need ultrasonic) DMSO : 10 mg/mL (24.29 mM; ultrasonic and warming and heat to 80°C)
体内研究	Cyclopamine causes durable regression of xenograft tumors. Tumors in Cyclopamine-treated animals, regress completely by 12 days. Cyclopamine (1.2 mg) treatment blocks tumour formation of human pancreatic adenocarcinoma cells after transplantation into nude mice.
体外研究	Treatment with small molecule Hh inhibitors such as HhAntag and the natural product Cyclopamine, both binding to Smo, induces tumor remission in a genetic mouse model of medulloblastoma. Cyclopamine is a Hedgehog (Hh) pathway antagonist. Cyclopamine suppresses cell growth. Cyclopamine (3 μM) suppression of Hh pathway activity and growth in digestive tract tumour cell lines correlates with expression of PTCHmRNA. Cyclopamine is a steroidal alkaloid that inhibits Hh signalling through direct interaction with Smo.
文献	•Cell Death Differ. 2021 Jul;28(7):2221-2237. •Cell Death Dis. 2019 Sep 12;10(9):681. •Pharmacol Res. 2021 Jan 26;105460. •Oxid Med Cell Longev. 09 Jul 2021. •Int J Nanomedicine. 2017 Apr 20;12:3267-3280. •Biochem Pharmacol. 2021 May 6;190:114593. •Front Pharmacol. 2018 Jun 26;9:674. •iScience. 2019 Sep 27;19:1248-1259. •J Cell Mol Med. 2021 Jun 2. •J Cell Mol Med. 2021 Aug;25(16):8015-8027. •Cell Death Discov. 2021 May 18;7(1):115. •FASEB J. 2018 Oct;32(10):5703-5715. •J Genet Genomics. 2018 May 20;45(5):237-246. •Life Sci. 2017 Dec 15;191:82-89. •Neurochem Res. 2016 Apr;41(4):687-95. •Exp Cell Res. 2021 Jan 15;398(2):112420. •Biochem Biophys Res Commun. 2020 May 28;526(2):314-320. •Connect Tissue Res. 2020 Jun 10;1-11. •Cancer Biother Radiopharm. 2021 Dec 31. •Exp Biol Med. 2020 Feb;245(3):213-220. •Hematology. 2022 Dec;27(1):1-10.
纯度及产品资料	98%

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