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抑制剂/激活剂

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凋亡与自噬

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Dibutyryl-cAMP, sodium salt

Dibutyryl-cAMP, sodium salt 布拉地新钠盐；二丁酰环磷腺苷钠盐

Bucladesine sodium是一种细胞可渗透性 PKA 激活剂，通过模拟内源性 cAMP 发挥作用。Dibutyryl-cAMP (Bucladesine)也是一种 phosphodiesterase (PDE) 抑制剂。

货号：
TK0485
规格：

25mg

50mg

100mg
价格：
￥0.00

产品参数

CAS No.	16980-89-5
生物活性	Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator. Bucladesine sodium salt raises the intracellular levels of cAMP. Bucladesine sodium salt is also a phosphodiesterase (PDE) inhibitor. Bucladesine sodium salt has anti-inflammatory activity and can be used for impaired wound healing.
分子式	C18H23N5NaO8P
分子量	491.37
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder, -20°C ,3 years
溶解性数据	DMSO : 170 mg/mL (345.97 mM; Need ultrasonic)，H2O : ≥ 50 mg/mL (101.76 mM)
体内研究	Intrahippocampal infusion of Bucladesine into the CA1 region (male Albino-Wistar rats) can cause an improvement in spatial memory in maze task. Bilateral infusion of 10 μM and 100 μM Bucladesine leads to a significant reduction in escape latency and travel distance (showing an improvement in spatial memory). Bucladesine via activation of PKA and induction of cAMP/PKA pathway improved spatial memory retention.
体外研究	Both choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) mRNA increased approximately fourfold after treatment of PC12 cells with Bucladesine (dibutyryl cyclic AMP; dbcAMP). ChAT and PKA activity are also increased by Bucladesine.
纯度及产品资料	98%

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