>>

>>

抑制剂/激活剂

>>

凋亡与自噬

>>

ITD-1

ITD-1 是第一个选择性的 TGFβ 受体抑制剂，IC50 为 460 nM。

货号：
TK0483
规格：

1mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	1099644-42-4
生物活性	ITD-1 is the first selective TGFβ receptor inhibitor with an IC50 of 460 nM.
分子式	C27H29NO3
分子量	415.52
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 28 mg/mL (67.39 mM; Need ultrasonic and warming)
体外研究	ITD-1 potently blocks phosphorylation of the effector SMAD2/3 proteins induced by TGFβ2, and only minimally in response to Activin A. HEK293T cells are transfected with a Smad4 response element driving luciferase (SBE4-Luc) to test whether ITD-1 blocks Activin A/Nodal and/or TGFβ signaling, which utilize the same intracellular signaling cascade through Smad4. ITD-1 strongly inhibits TGFβ2 signaling with similar efficacy (92% vs. 99% respectively), but with lower potency compared to SB-431542, an ACVR1B/TGFBR1 kinase inhibitor (IC50= 850nM vs. 70nM respectively), and is a weak and partial inhibitor of Activin A signals. ITD-1 selectively enhances the differentiation of uncommitted mesoderm to cardiomyocytes, but not to vascular smooth muscle and endothelial cells. ITD-1 reveals an unexpected role for TGFβ signaling in controlling cardiomyocyte differentiation from multipotent cardiovascular precursors.
文献	•ACS Comb Sci. 2019 Dec 9;21(12):805-816. •Oncotarget. 2017 Dec 14;9(3):3188-3197.
纯度及产品资料	98%

推荐产品