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β-Amyloid (1-40)

β-Amyloid (1-40)

β-Amyloid (1-40) 是阿尔茨海默病患者脑斑块中发现的主要蛋白质。

货号：
TK0462
规格：

500ug

1mg

5mg
价格：
￥0.00

产品参数

CAS No.	131438-79-4
生物活性	β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease.
分子式	C194H295N53O58S
分子量	4329.82
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder, -20°C ,3 years
溶解性数据	DMSO : 100 mg/mL (23.10 mM; Need ultrasonic),H2O : 100 mg/mL (23.10 mM; Need ultrasonic)
体内研究	Chronic infusion of β-Amyloid (1-40) into rat cerebroventricle leads to deficit in spatial and non-spatial memory formation. Chronic treatment of β-Amyloid (1-40) does not change lever-pressing performance significantly, but performance declined significantly 30 days after termination of the chronic daily regimen. The soluble unaggregated form of β-Amyloid (1-40), injected into the dorsal hippocampus, does not appear to have behavioral effects on performance or short-term working memory in rats, but multiple repeat injections produced performance decrements several weeks later. Repeated injection of β-Amyloid (1-40) through indwelling cannulae shows promise for development of an animal model of Alzheimer's disease.
体外研究	β-Amyloid (1-40) and (1-42) are major components of senile plaque amyloids, are physiological peptides present in the brain, cerebrospinal fluid (CSF) and plasma. The levels of CSF β-Amyloid (1-40) and (1-42) show a U-shaped natural course in normal aging.Chronic infusion of beta-amyloid (1-40) for 14 days into the rat cerebroventricle decreased the activity of soluble protein kinase C (PKC) in the hippocampus. Subcellular translocation of PKC to membrane fraction in hippocampal slices of rats treated with beta-amyloid (1-40) is completely abolished under acute stimulation with 0.5 microM phorbol-dibutyrate (PDBu).The further aggregation of β-Amyloid (1-40)
纯度及产品资料	98%

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