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抑制剂/激活剂

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凋亡与自噬

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Chlorpromazine HCl

Chlorpromazine HCl 盐酸氯丙嗪

Chlorpromazine HCl是一种多巴胺和钾离子通道抑制剂，对内向整流钾电流和与时间无关的外向电流IC50分别为6.1和16 μM。

货号：
TK0461
规格：

500mg

1g

5g
价格：
￥0.00

产品参数

CAS No.	69-09-0
生物活性	Chlorpromazine hydrochloride is an antagonist of the dopamine D2, 5HT2A, potassium channel and sodium channel. Chlorpromazine binds with D2 and 5HT2A with Kis of 363 nM and 8.3 nM, respectively.
分子式	C17H20Cl2N2S
分子量	355.33
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder, -20°C ,3 years
溶解性数据	DMSO : ≥ 60 mg/mL (168.86 mM)
体内研究	Chlorpromazine (2 mg/kg, i.p.)-induced neurobehavioural abnormalities (NAs) are characterized by significant increase in cataleptic behaviour and loared spontaneous activity reaction time in mice. Chlorpromazine (1 or 5 mg/kg, i,p.) prevents KET from increasing average spectral power of delta and gamma-high bands on the 5th and 10th days of treatment in rats.
体外研究	Chlorpromazine (3, 10, 20, 40, and 60 μM) decreases the peak currents of hNav1.7 in a concentration-dependent manner, with IC50 of 25.9 μM with a Hill coefficient of 2.3. Chlorpromazine (25 μM) produces strong use-dependent inhibition of the hNav1.7 current. Chlorpromazine blocks the hNav1.7 channel, independent of calmodulin. Chlorpromazine blocks HERG potassium channels with an IC50 value of 21.6 μM and a Hill coefficient of 1.11. Chlorpromazine (1, 10, 100 μM) blocks HERG potassium channels expressed in Xenopus laevis oocytes in a concentration-dependent manner. Chlorpromazine blocks HERG potassium channels in the activated state.
纯度及产品资料	98%

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