>>

>>

抑制剂/激活剂

>>

凋亡与自噬

>>

β-Lapachone ARQ-501; NSC-26326

β-Lapachone (ARQ-501;NSC-26326) 是一种天然的萘醌类化合物，是拓扑异构酶 I (topoisomerase I) 抑制剂，通过抑制细胞周期进程来诱导细胞凋亡。

货号：
TK0444
规格：

1mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	4707-32-8
生物活性	β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.
分子式	C15H14O3
分子量	242.27
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 50 mg/mL (206.38 mM; Need ultrasonic) Ethanol : 8.33 mg/mL (34.38 mM; Need ultrasonic)
体内研究	β-Lapachone (0.066%) ameliorates cisplatin-induced renal injury and when in combination with cisplatin, the affect is more significant in mice. β-Lapachone increases Mre11-Rad50-Nbs1 (MRN) complex expression in mice.
体外研究	β-Lapachone is a topoisomerase I inhibitor. β-Lapachone (25 μM) inhibits camptothecin-induced DNA cleavage. β-Lapachone (10-40 μM) significantly reduces the colony-forming ability of CHO cells, and is cytotoxic in S phase. β-Lapachone at above 10 μM, causes a heavy DNA-strand breaks in CHO cells. β-Lapachone (10 μM) suppresses JCPyV replication in IMR-32 cells. β-Lapachone (1.0 µM) potently affects JCPyV propagation in JCI cells. β-Lapachone (0.01-0.1 μM) inhibits VP1 production in JCI cells.
文献	•J Nanobiotechnology. 2021 Sep 4;19(1):261. •ACS Appl Mater Interfaces. 2019 Aug 28;11(34):30551-30565. •J Mol Med (Berl). 2019 Aug;97(8):1183-1193.
纯度及产品资料	98%

推荐产品