Lactacystin 是一种有效的、口服活性、不可逆的、细胞渗透性的，选择性的 20S 蛋白酶体 (proteasome) 抑制剂 (IC50 = 4.8 μM)。Lactacystin 还能抑制溶酶体酶组织蛋白酶 A (cathepsin A)。Lactacystin 抑制细胞生长，诱导细胞凋亡 (apoptosis) 和周期阻滞，并具有抗病毒和抗氧化活性。Lactacystin 诱导神经突生长，诱发高血压。Lactacystin 在癌症、神经系统疾病、高血压和疟疾等方面具有研究潜力。
| CAS No. | 133343-34-7 |
| 生物活性 | Lactacystin, an antibiotic Streptomyces spp. metabolite, is a potent and selective proteasome inhibitor with an IC50 of 4.8 μM for 20S proteasome. Lactacystin also inhibits the lysosomal enzyme cathepsin A. Lactacystin inhibits cell growth and induces neurite outgrowth. |
| 分子式 | C15H24N2O7S |
| 分子量 | 376.43 |
| 储存条件 | Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month |
| 体内研究 | Lactacystin (microinjection; 2 µg) induces a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice. |
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