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抑制剂/激活剂

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凋亡与自噬

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ALW-II-41-27 Eph receptor tyrosine kinase inhibitor

ALW II-41-27 (compound 7) 是一种有效的 Eph receptor tyrosine kinase 的抑制剂，对EphA2的Kd值为12 nM。

货号：
TK0433
规格：

1mg

5mg
价格：
￥0.00

产品参数

CAS No.	1186206-79-0
生物活性	ALW-II-41-27 is a Eph family tyrosine kinase inhibitor with an IC50 of 11 nM for Eph2.
分子式	C32H32N5O2F3S
分子量	607.69
储存条件	Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶解性数据	DMSO : ≥ 47 mg/mL (77.34 mM)
体外研究	ALW-II-41-27 inhibits Ba/F3 cells transformed with Tel fusions of EphA3, Kit, Fms, KDR, FLT1, FGR, Src, Lyn, Bmx, and Bcr-Abl with an EC50 below 500 nM. ALW-II-41-27 exhibits cross reactivity with Bcr-Abl. ALW-II-41-27 inhibits b-raf, CSF1R, DDR1, DDR2, EphA2, EphA5, EphA8, EphB1, EphB2, EphB3, Frk, Kit, Lck, p38α, p38β, PDGFRα, PDGFRβ, and Raf1 and many more demonstrating how introduction of the thiophene group can have a tremendous impact on kinase selectivity.

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