>>

>>

抑制剂/激活剂

>>

凋亡与自噬

>>

NU7441 (KU-57788)

NU7441 (KU-57788) NU7441

NU7441 (KU-57788)是一种高度有效的，选择性DNA-PK抑制剂，在无细胞试验中IC50为14 nM，也会抑制 mTOR 和 PI3K，对应的IC50值分别为1.7 μM和5 μM。它可降低NHEJ的频率，而增强Cas9介导DNA剪接后发生的同源重组修复率。

货号：
TK0415
规格：

2mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	503468-95-9
生物活性	KU-57788 (NU7441) is a highly potent and selective DNA-PK inhibitor with an IC50 of 14 nM. KU-57788 is an NHEJ pathway inhibitor. KU-57788 also inhibits PI3K and mTOR with IC50s of 5.0 and 1.7 μM, respectively.
分子式	C25H19NO3S
分子量	413.49
储存条件	Powder -20℃ 3 years
溶解性数据	DMSO : 6.67 mg/mL (16.13 mM; ultrasonic and warming and heat to 60°C)
体内研究	KU-57788 (0.5 to 10 µM) inhibits the growth of liver cancer HepG2 cells dose- and time-dependently. KU-57788 reduces pDNA-PKcs (S2056) protein expression in liver cancer cells. Furthermore, double treatment of KU-57788 and 60Coγ IR affects DNA damage repair. KU-57788 weakly inhibits BRD4 and BRDT with IC50s of 1 μM and 3.5 μM, respectively. KU-57788 is solvent-exposed in BRD4, this inhibitor can be classified as a Type I BRD inhibitor. KU-57788 reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
体外研究	NU7441 (0.5 to 10 µM) inhibits the growth of liver cancer HepG2 cells dose- and time-dependently. NU7441 reduces pDNA-PKcs (S2056) protein expression in liver cancer cells. Furthermore, double treatment of NU7441 and 60Coγ IR affects DNA damage repair. NU7441 is solvent-exposed in BRD4, this inhibitor can be classified as a Type I BRD inhibitor. NU7441 reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
文献	暂无相关参考文献
纯度及产品资料	98%

推荐产品