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抑制剂/激活剂

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凋亡与自噬

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SC79

SC79是一种大脑渗透性Akt磷酸化激活剂，也是一种Akt-PH域易位抑制剂。

货号：
TK0402
规格：

1mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	305834-79-1
生物活性	SC79, a unique specific and BBB permeable Akt activator, activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt.
分子式	C17H17ClN2O5
分子量	364.78
储存条件	Powder -20℃ 3 years
溶解性数据	DMSO : ≥ 100 mg/mL (274.14 mM)
体内研究	SC79 treatment, even at much high dose (0.4 mg/g of body weight), does not induce any detectable changes in body weight, survival rate, appearance, and behavior in mice. SC79 (10 mg/kg, i.p.) Protects C57BL/6 mice from fas-induced fulminant hepatic failure. SC79 protects hepatocytes from TNFα-mediated apoptosis and mice from Gal/LPS-induced liver injury and damage.
体外研究	SC79 augmentes Akt phosphorylation at both the Thr308 and S473 sites. SC79 (10.96 μM) induces cytosolic phosphorylation of Akt. SC79 enhances IGF1-induced Akt phosphorylation in both serum-starved cells and cells grown in serum-rich medium. SC79 reduces neuronal excitotoxicity and prevents stroke-induced neuronal death. SC79 suppresses PHAKTM-GFP plasma membrane translocation. SC79 restores proliferation of BRAT1 knockdown cells, and reduces the production of superoxide in mitochondria of MitoSox positive cells. SC79 upregulates FLIPL/S expression and consequently suppresses caspase-8 activation.
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纯度及产品资料	≥98%

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