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抑制剂/激活剂

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凋亡与自噬

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Selonsertib (GS-4997)

Selonsertib (GS-4997) GS-4997

Selonsertib (GS-4997) 是一种具有高度选择性的、有效的ASK1抑制剂，具有潜在的消炎、抗肿瘤的、抗纤维化活性。

货号：
TK0392
规格：

1mg

2mg

5mg

10mg
价格：
￥0.00

产品参数

CAS No.	1448428-04-3
生物活性	Selonsertib (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis.
分子式	C24H24FN7O
分子量	445.49
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : ≥ 31 mg/mL (69.59 mM)
体外研究	Selonsertib (GS-4997) is a clinical stage ASK1 inhibitor, which has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain.
文献	•J Hazard Mater. 2021, 125179. •Cell Biosci. 2021 Jan 7;11(1):9. •Research Square Preprint. 2021 Jul.
纯度及产品资料	98%

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