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抑制剂/激活剂

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凋亡与自噬

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VX-11e

VX-11e 是一种高效的，具有选择性的，可口服的 ERK 抑制剂，Ki 值 < 2 nM。

货号：
TK0388
规格：

1mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	896720-20-0
生物活性	VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK with Ki < 2 nM.
分子式	C24H20Cl2FN5O2
分子量	500.35
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : ≥ 100 mg/mL (199.86 mM)
体内研究	VX-11e is orally bioavailable in both rat and mice. VX-11e (50 mg/kg, p.o.) results in robust inhibition of pRSK, and inhibits tumor growth in NSG mice bearing human melanoma RPDX tumors. VX-11e with BKM120 significantly improves tumor growth inhibition.
体外研究	VX-11e is active in the HT29 cell proliferation assay (IC50=48 nM).
文献	•Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093. •J Invest Dermatol. 2020 Sep 9;S0022-202X(20)32055-8. •ACS Comb Sci. 2019 Dec 9;21(12):805-816. •Stem Cells Dev. 2020 Jul 1;29(13):863-875. •Oncotarget. 2016 Apr 26;7(17):23300-11. •J Prac Med. 2016, 32 (11): 1734-1737. •Harvard Medical School LINCS LIBRARY
纯度及产品资料	98%

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