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抑制剂/激活剂

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凋亡与自噬

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Hydroxychloroquine Sulfate

Hydroxychloroquine Sulfate 硫酸羟氯喹; HCQ sulfate

Hydroxychloroquine (HCQ) Sulfate是一种抗疟疾药，用于治疗系统性红斑狼疮，类风湿关节炎等自身免疫病，炎症以及皮肤病。它也是autophagy和toll-like receptor (TLR) 7/9的抑制剂。

货号：
TK0375
规格：

5mg

10mg

50mg

200mg
价格：
￥0.00

产品参数

CAS No.	747-36-4
生物活性	Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro.
分子式	C18H28ClN3O5S
分子量	433.95
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶解性数据	H2O : 110 mg/mL (253.49 mM; Need ultrasonic and warming) DMF : 1.4 mg/mL (3.23 mM; Need ultrasonic) DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)
体内研究	Hydroxychloroquine sulfate is prescribed for the treatment of lupus, and both Hydroxychloroquine sulfate and its analog chloroquine inhibit TLR7 and 9 signaling.
体外研究	Hydroxychloroquine sulfate is a synthetic antimalarial drug derived from 4-aminoquinoline; it has been used for several decades for the treatment of some rheumatic diseases such as rheumatoid arthritis (RA). Five micromolar Hydroxychloroquine sulfate or chloroquine also has no measurable effect on intracellular pH, although these concentrations can inhibit TLR9 or 7 signaling induced by DNA or RNA ligands.
文献	•Nat Biomed Eng. 2021 Nov 8. •Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121. •Autophagy. 2022 Jan 6;1-20. •Autophagy. 2021 Sep 15;1-19. •Nat Commun. 2021 Aug 16;12(1):4964. •Theranostics. 2020 Apr 27;10(13):5829-5844. •Acta Pharm Sin B. 2021. Jun 16. •Cell Discov. 2020 Mar 18;6:16. •J Control Release. 2020 Jan 28;320:304-313. •Cell Rep. 2021, 108959. •BMC Med. 2021 Oct 15;19(1):247. •Cell Death Dis. 2020 Apr 24;11(4):279. •Pharmacol Res. 2021 Apr 30;169:105642. •Clin Chem. 2019 Dec;65(12):1522-1531. •J Autoimmun. 2019 May;99:39-47. •Am J Cancer Res. 2020 Nov 1;10(11):3896-3910. •Acta Pharmacol Sin. 2021 Feb 19. •Clin Sci (Lond). 2019 Aug 14;133(15):1759-1777. •Front Bioeng Biotechnol. 2020 May 8;8:378. •Biochem Pharmacol. 2021 Dec 28;114904. •Aging. 2021 Mar 10;13(6):8421-8439. •Phytomedicine. 2021, 153465. •Life Sci. 2021 Oct 26;120095. •Life Sci. 2020 Apr 1;246:117366. •Life Sci. 2020 Feb 15;243:117277. •Cell Signal. 2019 Feb;54:17-26. •Biochem Biophys Res Commun. 2020 Dec 10;533(3):474-480. •Research Square Preprint. 2021 Oct. •Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários. 2020 Sep.
纯度及产品资料	98%

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