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抑制剂/激活剂

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凋亡与自噬

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Hydrocortisone 氢化可的松; Cortisol

Hydrocortisone是一种由肾上腺产生的类固醇激素或糖皮质激素。

货号：
TK0367
规格：

50mg

500mg
价格：
￥0.00

产品参数

CAS No.	50-23-7
生物活性	Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
分子式	C21H30O5
分子量	362.46
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据	DMSO : ≥ 31 mg/mL (85.53 mM) H2O : < 0.1 mg/mL (insoluble)
体外研究	Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells. Hydrocortisone supplementation of the serum-reduced cell differentiation medium leads to a significant increase in TER across the hCMEC/D3 monolayer. Hydrocortisone-treated Dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibit production of IFN-γ but induce an increased release of IL-4 and no change in IL-5. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan as is release of histamine from resident mast cells.
文献	•Nature. 2021 Jan;589(7843):620-626. •Cancer Commun (Lond). 2021 Jun 10. •JCI Insight. 2021 Jun 22;6(12):142838. •Chem Biol Interact. 2022 Jan 5;109798. •Cancer Manag Res. 2019 Jun 21;11:5557-5572. •Exp Cell Res. 2020 Aug 1;393(1):112054. •Oncol Lett. 2021 Apr 27. •Exp Ther Med. 2021 Jun 3. •Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários. 2020 Sep.
纯度及产品资料	98%

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