>>

>>

抑制剂/激活剂

>>

凋亡与自噬

>>

T-5224

T-5224 是一种转录因子 c-Fos/activator protein (AP)-1 的选择性抑制剂，并具有抗炎作用。T-5224 可特异性地抑制 c-Fos/c-Jun 的DNA结合活性和 IL-1β 诱导的 Mmp-3、Mmp-13 和 Adamts-5 转录的上调。

货号：
TK0357
规格：

1mg

5mg

10mg
价格：
￥0.00

产品参数

CAS No.	530141-72-1
生物活性	T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription.
分子式	C29H27NO8
分子量	517.53
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder, -20°C ,3 years
溶解性数据	DMSO : 100 mg/mL (193.23 mM; Need ultrasonic)
体内研究	Administration of T-5224 (300 mg/kg, p.o.) after intraperitoneal injection of LPS impartes appreciable protection against acute elevations in serum levels of TNFα, HMGB1, ALT/AST as well as in liver tissue levels of MIP-1α and MCP-1, and reduces the lethality (27%).G2 is observed in rat and monkey liver microsomes as a major metabolite of T-5224, suggesting that G2 is not a human-specific metabolite.T-5224 (300 mg/kg, p.o.) inhibits the production of TNF-alpha and other downstream effectors in C57BL/6 mice.
体外研究	T-5224 inhibits in-vitro production of the mediators MMP-1, MMP-3, IL-6 and TNF-α by IL-1β-stimulated human synovial SW982 cells with the mean IC50 of about 10 μM.T-5224 (0-80 μM) significantly inhibits the invasion, migration, and MMP activity of HSC-3-M3 cells in a dose-dependent manner.
纯度及产品资料	98%

推荐产品