Elesclomol (STA-4783)是一种新型有效的oxidative stress诱导剂，在肿瘤细胞中引起促凋亡作用。Elesclomol 特异性结合铁氧还蛋白 1 (FDX1) α2/α3 螺旋和 β5 链，抑制 FDX1 介导的 Fe-S 簇生物合成。Elesclomol (STA-4783)是一种有效的铜离子载体，可用于铜死亡（cuproptosis）的研究。
| CAS No. | 488832-69-5 |
| 生物活性 | Elesclomol (STA-4783) is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol shows antitumor activity against a broad range of cancer cell types. Elesclomol is also a highly lipophilic Cu-binding molecule. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research. |
| 分子式 | C19H20N4O2S2 |
| 分子量 | 400.52 |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存条件 | Powder -20°C 3 years |
| 溶解性数据 | DMSO :100 mg/mL (249.68 mM; Need ultrasonic) |
| 体内研究 | Elesclomol (10 mg/kg; subcutaneous injection; every three days from post-natal day 5 to 26 and once weekly until post-natal day 54) treatment ameliorates severe cardiac pathology with a partial reduction in hypertrophy. Cardiac [Cu] increased with Elesclomol treatment from a vehicle knockout level of 34 to 55%. Elesclomol escorted copper to the mitochondria and increased cytochrome c oxidase levels in the brain. Elesclomol prevents detrimental neurodegenerative changes and improved the survival of the mottled-brindled mouse. |
| 体外研究 | Elesclomol (200 nM; 18 hours) treatment increases the number of early and late apoptotic cells in HSB2 cells. Elesclomol induces apoptosis in cancer cells through the induction of oxidative stress. Elesclomol significantly inhibits the cell viability of SK-MEL-5, MCF-7, and HL-60 cells with IC50 values of 110 nM, 24 nM and 9 nM, respectively. |
| 文献 | •Nat Chem Biol. 2019 Jul;15(7):681-689. •Biomolecules. 2019 Jul 24;9(8):298. •Virol Sin. 2021 Sep 12;1-12. •bioRxiv. March 24, 2018. •Patent. US9808434B2. •Patent. US20160354327A1. •The Graduate School of Engineering and Science. Bilkent University. 2014 Aug. |
| 纯度及产品资料 | 98% |
邮箱：info@TianyaBio.com
电话：020-3107 8154
地址：广州市番禺区兴业大道东路1078号2-50
微信公众号
微信客服
