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抑制剂/激活剂

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凋亡与自噬

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JSH-23

JSH-23是一种NF-κB转录活性抑制剂，其对LPS刺激的RAW 264.7 中的核因子（NF）-κB 转录活性具有抑制作用，IC50为 7.1 μM，并能干扰 LPS 诱导的 NF-κB核转位，而不影响 IκB 降解。

货号：
TK0346
规格：

1mg

2mg

5mg
价格：
￥0.00

产品参数

CAS No.	749886-87-1
生物活性	JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC50 of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation.
分子式	C16H20N2
分子量	240.34
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : ≥ 56 mg/mL (233.00 mM)
体内研究	JSH-23 (1 mg/kg, 3 mg/kg; orally administered; daily; for 2 weeks) significantly reverses the nerve conduction and nerve blood flow deficits seen in diabetic rats.
体外研究	JSH-2 (1-300 μM; 24 hours) at <100 μM does not show significant cytotoxic effects on the RAW 264.7 cells. Nuclear amount of NF-κB p65 is markedly increased upon exposure to LPS for 1 h. Treatment of JSH-23 (30 μM; 1 hours) to LPS- stimulated RAW 264.7 cells decreases nuclear content of NF-κB p65 in a dose-dependent manner.
纯度及产品资料	98%

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