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抑制剂/激活剂

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凋亡与自噬

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Quercetin 槲皮素

Quercetin是蔬菜水果和白酒中的天然黄酮类化合物，是一种体外重组Sirt1蛋白的激活剂同时也是PI3K抑制剂，IC50为2.4 – 5.4 μM。Quercetin 可诱导凋亡和保护性的自噬。Phase 4。

货号：
TK0342
规格：

500mg

1g

5g
价格：
￥0.00

产品参数

CAS No.	117-39-5
生物活性	Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.
分子式	C15H10O7
分子量	302.24
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : ≥ 100 mg/mL (330.86 mM) Ethanol : 16.67 mg/mL (55.15 mM; Need ultrasonic)
体内研究	Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.
体外研究	Quercetin is a type of plant-based chemical, or phytochemical, used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin is a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin strongly abrogates PI3K and Src kinases, mildly inhibits Akt1/2, and slightly affected PKC, p38 and ERK1/2. Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation.
文献	•Environ Pollut. 25 August 2021, 118036. •Comput Struct Biotechnol J. 1 October 2021. •J Inflamm Res. 2021 Dec 7;14:6601-6618. •Osteoarthritis Cartilage. 2021 Mar;29(3):413-422. •Eur J Med Chem. 2018 Mar 25;148:63-72. •J Mol Liq. 23 November 2021, 118164. •Genomics. 2021 Jun 7;S0888-7543(21)00220-2. •Aging (Albany NY). 2021 Nov 25;13(22):24753-24767. •Aging. 2020 Jun 25;12(12):11337-11348. •J Agric Food Chem. 2020 Jul 29;68(30):8050-8056. •Life Sci. 2020 Sep 15;257:118116. •Inflamm Res. 2020 Dec;69(12):1201-1213. •Molecules. 2020 Apr 23;25(8):1980. •Exp Cell Res. 2020 Aug 1;393(1):112054. •Virus Res. 2021 Sep 4;198556. •Insects. 2018 Jun 29;9(3). pii: E77. •Evid-Based Compl Alt. 26 Aug 2021. •Thorac Cancer. 2021 Mar 11. •Exp Ther Med. 2021 Mar 8. •Int J Insect Sci. 2018 Feb 28;10:1179543318758409. •Research Square Preprint. 2021. Jul. •International Journal of Human Anatomy. 2020 Dec.
纯度及产品资料	98%

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