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抑制剂/激活剂

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凋亡与自噬

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Blebbistatin

Blebbistatin 是一种选择性的非肌肉肌球蛋白 II (NMII) 抑制剂，可促进角膜内皮细胞的定向迁移并加速伤口愈合，并更好地保留细胞连接完整性和屏障功能。

货号：
TK0302
规格：

1mg

2mg

5mg

5mg
价格：
￥0.00

产品参数

CAS No.	674289-55-5
生物活性	Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function.
分子式	C18H16N2O2
分子量	292.33
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 25 mg/mL (85.52 mM; Need ultrasonic)
体内研究	Blebbistatin (0.05 mL, 20 μM; intracameral injection; daily; for 6 days; New Zealand white rabbits) treatment promotes wound healing in rabbit corneal endothelial scraping model.
体外研究	The therapeutic potential of targeting NMII to enhance CEC migration is investigated using bovine corneal endothelial cells (BCECs). Blebbistatin, a direct myosin motor inhibitor, promotes migration and directional persistence in CECs through decreasing actin retrograde flow and increasing lamellipodial protrusion persistence to accelerate wound healing in vitro.
文献	•Cell Res. 2021 Sep;31(9):951-964. •Adv Healthc Mater. 2022 Jan 10;e2101657. •Chemosphere. 2020 Jan;239:124608. •Mat Sci Eng C-Mater. 2021, 111939. •Agricultural and Mechanical College, Louisiana State University. 2019 Nov.
纯度及产品资料	98%

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