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抑制剂/激活剂

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凋亡与自噬

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Mdivi-1 Mitochondrial division inhibitor 1

Mdivi-1 是选择性的发动蛋白相关蛋白 1 (Drp1) 抑制剂。Mdivi-1 是一种有效的线粒体分裂/线粒体自噬 (mitophagy) 抑制剂。

货号：
TK0295
规格：

1mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	338967-87-6
生物活性	Mdivi-1 is a selective dynamin-related protein 1 (Drp1) inhibitor. Mdivi-1 is a mitochondrial division/mitophagy inhibitor.
分子式	C15H10Cl2N2O2S
分子量	353.22
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 160 mg/mL (452.98 mM; Need ultrasonic)
体内研究	The mitochondrial division DRP, Dnm1, is the target of mdivi-1 in vivo. Mdivi-1 quantitatively blocks GMPPCP- dependent Dnm1 self-assembly in a concentration range similar to its effects on mitochondrial division in vivo. Mdivi-1 (50 mg/kg, i.p.) significantly decreases GFAP protein expression in the normal mouse retina.
体外研究	Mdivi-1 inhibits Dnm1 GTPase activity in a dose-dependent manner, with an estimated EC50 of 1-10 μM. Mdivi-1 increases the apparent K0.5 for GTP, lowers the apparent Vmax for GTP hydrolysis, and causes an increase in the Hill coefficient observed for GTP in the Dnm1 GTP hydrolysis reaction. Cells treated with mdivi-1 display decreased cytochrome c release and a reduced rate of phosphatidylserine exposure on their surface following apoptosis induction, consistent with an inhibition of apoptosis and with previous studies using other strategies to compromise DRP1 activity. Mdivi-1 results in apoptotic cell death in ischemic retina.
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纯度及产品资料	98%

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