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抑制剂/激活剂

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凋亡与自噬

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Pirinixic acid Wy-14643

Pirinixic acid (Wy-14643) 是一种有效的 PPARα 激动剂，对鼠的 PPARα 和 PPARγ 的 EC50 值分别为 0.63 μM, 32 μM，对人的 PPARα，PPARγ 和 PPARδ 的 EC50 值分别为 5.0 μM，60 μM，35 μM。

货号：
TK0276
规格：

10mg

50mg

100mg
价格：
￥0.00

产品参数

CAS No.	50892-23-4
生物活性	Pirinixic acid (Wy-14643) is a potent agonist of PPARα, with EC50s of 0.63 μM, 32 μM for murine PPARα and PPARγ, and 5.0 μM, 60 μM, 35 μM for human PPARα, PPARγ and PPARδ, respectively.
分子式	C14H14ClN3O2S
分子量	323.80
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 100 mg/mL (308.83 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
体内研究	Pirinixic acid (Wy-14643; 10 mg/kg, i.v.) decreases hepatic injury and lipid peroxidation (MDA) levels in obese rats. Pirinixic acid also causes increased SIRT1 activity in Sham and ischemia-reperfusion (IR) group, but shows no effects on SIRT3 protein expression. Pirinixic acid enhances NAD, and ATP levels, and prevents endoplasmic reticulum stress (ERS) in rats.
体外研究	Pirinixic acid (Wy-14643) is an agonist of PPARα, with EC50s of 0.63 μM, 32 μM for murine PPARα and PPARγ, and 5.0 μM, 60 μM, 35 μM for human PPARα, PPARγ and PPARδ, respectively. Pirinixic acid (Wy-14643; 0, 10, 100 μM) enhances protein expression of PPAR-α in synovial fibroblasts. Pirinixic acid (0, 10, 100 μM) shows inhibitroy effects on NO and PGE2 production in LPS-stimulated synovial fibroblasts. Pirinixic acid also effectively downregulates expression of inflammatory mediators such as VCAM-1, ICAM-1, ET-1, and TF in synovial fibroblasts, blocks LPS-induced NF-kB activation, IkB phosphorylation, and NF-kB nuclear translocation in synovial fibroblasts, but Pirinixic acid shows no effects in PPAR-α silenced cells.
文献	•Theranostics. 2021 Jan 1;11(5):2247-2262. •Theranostics. 2020 Feb 18;10(8):3579-3593. •Environ Pollut. 2021, 117792. •Ecotoxicol Environ Saf. February 2022, 113173. •J Cell Mol Med. 2021 Dec 28. •PPAR Res. 2021 Apr 19;2021:6631605. •BMC Cancer. 2019 Dec 2;19(1):1166.
纯度及产品资料	98%

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