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抑制剂/激活剂

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凋亡与自噬

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Tubastatin A

Tubastatin A 是一种有效的，选择性HDAC6抑制剂，无细胞试验中IC50为15 nM，选择性远高于所有其他同工酶(1000倍)除了HDAC8(57倍)。Tubastatin A 可促进自噬并增加凋亡。

货号：
TK0268
规格：

2mg

5mg

10mg
价格：
￥0.00

产品参数

CAS No.	1252003-15-8
生物活性	Tubastatin A is a potent and selective HDAC6 inhibitor with an IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more).
分子式	C20H21N3O2
分子量	335.4
储存条件	Powder -20℃ 3 years
溶解性数据	DMSO : 12.5 mg/mL (37.27 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)
体内研究	Daily treatment of Tubastatin A at 0.5 mg/kg inhibits HDAC6 to promote Tregs suppressive activity in mouse models of inflammation and autoimmunity, including multiple forms of experimental colitis and fully major histocompatibility complex (MHC)-incompatible cardiac allograft rejection.
体外研究	Tubastatin A is substantially selective for all 11 HDAC isoforms and maintains over 1000-fold selectivity against all isoforms excluding HDAC8, where it has approximately 57-fold selectivity. In homocysteic acid (HCA) induced neurodegeneration assays, Tubastatin A displays dose-dependent protection against HCA-induced neuronal cell death starting at 5 μM with near complete protection at 10 μM. At 100 ng/mL Tubastatin A increases Foxp T-regulatory cells (Tregs) suppression of T cell proliferation in vitro. Tubastatin A treatment in CC12 cells would lead to myotube formation impairment when alpha-tubulin is hyperacetylated early in the myogenic process; however, myotube elongation occurs when alpha-tubulin is hyeperacetylated in myotubes. A recent study indicates that Tubastatin A treatment increases cell elasticity as revealed by atomic force microscopy (AFM) tests without exerting drastic changes to the actin microfilament or microtubule networks in mouse ovarian cancer cell lines, MOSE-E and MOSE-L.
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纯度及产品资料	98%

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