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抑制剂/激活剂

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凋亡与自噬

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Trichostatin A (TSA)

Trichostatin A (TSA) 曲古抑菌素A; TSA

TSA (Trichostatin A) 是一种HDAC抑制剂，无细胞试验中IC50为1.8 nM左右。

货号：
TK0263
规格：

2mg
价格：
￥0.00

产品参数

CAS No.	58880-19-6
生物活性	Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC.
分子式	C17H22N2O3
分子量	302.37
储存条件	Powder -20℃ 3 years
溶解性数据	DMSO : 25 mg/mL (82.68 mM; Need ultrasonic)
体内研究	Trichostatin A (500 μg/kg, s.c.) pronounces antitumor activity without causing any measurable toxicity in doses of up to 5 mg/kg by s.c. injection, in randomized controlled efficacy studies using the N-methyl-N-nitrosourea carcinogen-induced rat mammary carcinoma model.
体外研究	Trichostatin A is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC. Trichostatin A (TSA) inhibits proliferation of eight breast carcinoma cell lines with mean±SD IC50 of 124.4±120.4 nM (range, 26.4-308.1 nM). HDAC inhibitory activity of Trichostatin A is similar in all cell lines with mean IC50 of 2.4±0.5 nM (range, 1.5-2.9 nM). Trichostatin A (330 nM) increases Gαs protein expression in human myometrial cells, but does not increase Gαs mRNA levels. Trichostatin A (20-75 nM) induces minimal cytotoxicity to adipose-derived stem cells (ADSCs), and enhances the osteogenic differentiation capacity of ADSCs. In addition, Trichostatin A (0, 10, 100, 500 nM) dose-dependently decreases HDAC class I/II activity.
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纯度及产品资料	98%

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