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抑制剂/激活剂

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凋亡与自噬

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Seclidemstat SP-2577

Seclidemstat 是一种有效的非竞争性可逆 KDM1A (LSD1) 抑制剂 (Ki=31 nM, IC50)。Seclidemstat 促进 SWI/SNF 复合物突变卵巢癌的抗肿瘤免疫，并抑制病毒产生、病毒 DNA 复制和晚期基因表达。Seclidemstat 可用于尤文肉瘤的研究。

货号：
TK0260
规格：

1mg

5mg
价格：
￥0.00

产品参数

CAS No.	1423715-37-0
生物活性	Seclidemstat is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat can be used for the research of Ewing Sarcoma.
分子式	C20H23ClN4O4S
分子量	450.94
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 100 mg/mL (221.76 mM; Need ultrasonic)
体外研究	Seclidemstat (72 hours) inhibits SWI/SNF-mutation-dependent tumor cell proliferation with IC50 ranging from 0.013 to 2.819 μM (COV434, BIN67, SCCOHT-1, TOV21G, SKOV3, A427, H522, A549, H1299, G401, G402, HCC15 cells). Seclidemstat (72 hours) promotes endogenous retroviruses (ERVs) expression and activation of IFNβ pathway in SCCOHT cell lines (SCCOHT-1, BIN67, and COV434 cells). Seclidemstat (3 μM) promotes PD-L1 expression in SCCOHT COV 434 pIND 20 BRG1-2.7 cell line.
文献	•ACS Pharmacol Transl Sci. November 12, 2021. •bioRxiv. 2020 May.
纯度及产品资料	98%

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