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抑制剂/激活剂

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凋亡与自噬

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Vidofludimus 4sc-101; SC12267

Vidofludimus(4SC-101; SC12267)是免疫抑制剂，能抑制DHODH，在不影响淋巴细胞增殖的条件下抑制IL-17的分泌。

货号：
TK0245
规格：

1mg

5mg
价格：
￥0.00

产品参数

CAS No.	717824-30-1
生物活性	Vidofludimus(4SC-101; SC12267) is a novel immunosuppressive drug that inhibits DHODH; inhibits IL-17 secretion in vitro independently of effects on lymphocyte proliferation. IC50 value: Target: DHODH inhibitor in vitro: 4SC-101 is a potent inhibitor of human DHODH, inhibits lymphocyte proliferation, and uniquely blocks phytohemagglutinin-stimulated IL-17 production by lymphocytes [2]. in vivo: In vivo Vido treatment alone most effectively reduced macroscopic and histological pathology and the numbers of CD3+ T cells. In contrast, similarly reduced nuclear signal transducer and activator of transcription 3 (STAT3) binding and IL-17 levels were observed from animals treated with Vido alone and Vido + Uri. Vido improves TNBS-induced colonic inflammation by a unique dual mode of action [1]. Oral administration of 4SC-101 effectively improved both chronic DSS and acute TNBS colitis in mice. In these colitis models the overall efficacy profile of 4SC-101 was similar to that of dexamethasone [2].
分子式	C20H18FNO4
分子量	355.36
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : ≥ 46 mg/mL (129.45 mM)
纯度及产品资料	98%

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