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抑制剂/激活剂

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凋亡与自噬

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Verapamil HCl 盐酸维拉帕米；戊脉安

Verapamil HCl是L-型钙通道抑制剂，是第四类抗心律失常的药剂。Verapamil 可抑制 permeability-glycoprotein (P-gp) 和 CYP3A4。

货号：
TK0216
规格：

500mg

1g

5g
价格：
￥0.00

产品参数

CAS No.	152-11-4
生物活性	Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research.
分子式	C27H39ClN2O4
分子量	491.06
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	4°C, protect from light,*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据	H2O : 50 mg/mL (101.82 mM; Need ultrasonic),DMSO : 58.33 mg/mL (118.78 mM; Need ultrasonic)
体内研究	Given orally Verapamil is useful for the prophylaxis of atrioventricular reentry tachycardia, and also in modulating the atrioventricular nodal response in atrial fibrillation.Verapamil is injected i.v. into a femoral vein prior to ischemia. Verapamil (1 mg/kg) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion. Total arrhythmia scores are significantly increased when the heart is subjected to ischemia. Verapamil (1 mg/kg) significantly prevents the enhancement of total arrhythmia scores induced by ischemia.
体外研究	The EverFluor FL Verapamil (EFV) uptake by TR-iBRB2 cells is inhibited by cationic drugs, and inhibits by verapamil in a concentration-dependent manner with an IC50 of 98.0 μM.
纯度及产品资料	98%

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