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抑制剂/激活剂

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凋亡与自噬

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Panobinostat 帕比司他; LBH589; NVP-LBH589

Panobinostat (LBH589; NVP-LBH589) 是一种有效的口服非选择性 HDAC 抑制剂，具有抗肿瘤活性。Panobinostat 可诱导 HIV-1 virus 的产生，即使在较低的浓度范围 8-31 nM，也可刺激 HIV-1 在潜伏感染细胞中的表达。Panobinostat 诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)。Panobinostat 可用于难治性或复发性多发性骨髓瘤的研究。

货号：
TK0177
规格：

1mg

5mg

10mg

50mg

100mg
价格：
￥0.00

产品参数

CAS No.	404950-80-7
生物活性	Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma.
分子式	C21H23N3O2
分子量	349.43
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : ≥ 57 mg/mL (163.12 mM)
体内研究	Panobinosta (10, 20 mg/kg, i.p.) significantly slows tumor growth derived from Meso and NSCLC cells in vivo models. Panobinosta markedly increases acetylation of histone H3 and H4 of H69 human SCLC cells harvest from SCID mice. Panobinostat (5, 10 and 20 mg/kg i.p.) demonstrates a clear benefit of decreased tumor burden, significantly improves TTE and reduces bone density loss in a disseminated multiple myeloma mouse model.
体外研究	Panobinosta (LBH589) induces apoptosis of both MOLT-4 and Reh cells in a time- and dose-dependent manner. Panobinosta treatment results in histone (H3K9 and H4K8) hyperacetylation and regulation of cell-cycle control genes in Reh cells. Panobinostat exhibites potent antiproliferative activity in human NSCLC cell lines with the IC50 ranging from 5 to 100 nM.
文献	•Cancer Res. 2016 Dec 1;76(23):7001-7011. •Cancer Lett. 30 June 2021. •Front Immunol. 2021 Aug 31;12:701671. •Mol Ther Oncolytics. 2019 Feb 5;12:235-245. •PLoS Pathog. 2018 Sep 13;14(9):e1007267. •Cells. 2020 Jul 10;9(7):1661. •Commun Biol. 2021 Oct 29;4(1):1235. •Acta Pharmacol Sin. 2020 Aug 27. •Biomedicines. 2021, 9(12), 1873. •Cancer Cell Int. 2021 Jun 5;21(1):291. •Int J Oncol. 2020 Jun;56(6):1429-1441. •J Clin Endocrinol Metab. 2021 Jan 1;106(1):e232-e246. •J Virol. 2021 Jul 21;JVI0022721. •Int J Biochem Cell Biol. 2020 May;122:105734. •Eur J Pharmacol. 2020 May 15;875:173050. •Drug Des Devel Ther. 2018 Apr 30;12:1009-1017. •Gene. 2021 Sep 27;145977. •Cell Biol Int. 2021 Jan 27. •Neuroscience. 2021 Apr 13;S0306-4522(21)00185-8. •Insect Mol Biol. 2020 Feb;29(1):104-111. •J Recept Signal Transduct Res. 2020 Dec 1;1-9. •Arch Insect Biochem Physiol. 2021 Jun 1;e21823. •Pharmaceuticals. 2021, 14(12), 1244. •Research Square Preprint. 2021 Dec. •Neurooncol Adv. 17 July 2021. •Departamento de Biotecnología. 2020 Sep. •The Faculty For Chemie And Pharmazie, Albert-ludwigs-university Of Freiburg. 2019 Dec. •bioRxiv. 2019 Nov. •Patent. US20180263995A1. •China Biotechnology. 2016, 36(6): 9-17.
纯度及产品资料	98%

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