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抑制剂/激活剂

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凋亡与自噬

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Torin 1

Torin 1是一种有效的mTORC1/2抑制剂，在无细胞试验中IC50为2 nM/10 nM；作用于mTOR比作用于PI3K选择性高1000倍。

货号：
TK0167
规格：

1mg

2mg

5mg

10mg
价格：
￥0.00

产品参数

CAS No.	1222998-36-8
生物活性	Torin 1 is a potent inhibitor of mTOR with an IC50 of 3 nM. Torin 1 inhibits both mTORC1/2 complexes with IC50 values between 2 and 10 nM. Torin 1 is an effective inducer of autophagy.
分子式	C35H28F3N5O2
分子量	607.62
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20℃ 3 years
溶解性数据	DMSO : 2 mg/mL (3.29 mM; ultrasonic and warming and heat to 60°C)
体内研究	Torin1 (20 mg/kg, i.p.) is efficacious in a U87MG xenograft model, and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues.
体外研究	Torin1 (250 nM) completely inhibits proliferation and causes a G1/S cell cycle arrest, and decreases cell size to a greater degree than 50 nM rapamycin in wild-type MEFs. Torin1 has more than 800-fold selectivity between mTOR and PI3Kis, and is very selective relative to other PIKK family kinases with the exception of DNA-PK.
文献	暂无相关参考文献
纯度及产品资料	≥98%

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